Consistent with expectations, canonical luminal genes such as ESR1, GATA3, FOXA1, TFF1 and IGF1R were higher in ER+ samples compared to triple negative samples, while proliferation and mesenchymal genes such as SPRY2, SNAI2, FOSL1, MET and BUB1 were higher in triple negative cancers. This evidence concerns the gene SPRY2 and cancer.