TNFRSF1B and Chronic colitis: Given the up-regulated TNFR2 and MLCK expressions in the epithelial cells associated with pro-tumorigenic and pro-inflammatory cytokines expressions in the mucosal tissues from chronic colitis and CAC model, it was surmised that each of these complicated phenomena may be associated with the mechanisms by which tumorigenesis is induced in the context of IBD.