These results are consistent with the observations of the intercellular junctional complexes among cells under TEM, since chronic inflammation in the control group induced disruption of epithelial TJ, and treatments via both TNF blockade and MLCK suppression resulted in the restoration of the disrupted TJ in the non-tumor and tumor areas and in association with reduced CAC (Fig. 5F). This evidence concerns the gene MYLK and neoplasm.