TNF and neoplasm: Interestingly, q-PCR revealed that the expression levels of IL-1β, IL-6 and MIP-2 (Fig. 5D) as well as IFN-γ and TNF (data not shown) in the colonic tissue, especially in the tumor area, were suppressed by the treatment with ML-7 as well as with MP6-XT22 (Fig. 5D).