Finally, the relationship between log10 of amylin and either log10 of plasma Aβ1-42 (β = +0.146, SE = 0.025, P<0.0001) or log10 of plasma Aβ1-40 (β = +0.034, SE = 0.016, P = 0.04) as an outcome persisted after adjusting for age, gender, ethnicity, ApoE4, BMI, diabetes, stroke, creatinine and lipid profile including cholesterol, LDL and HDL (Model III). Here, APOE is linked to diabetes mellitus.