In the absence of ApoE4, the relationships between amylin and Aβ1-42 (β = +0.158, SE = 0.031, P<0.0001) or Aβ1-40 (β = +0.044, SE = 0.020, P = 0.03) in plasma still remained after adjusting for age, gender, ethnicity, BMI, diabetes, stroke, creatinine and the lipid profile (Tables 1 and 5). This evidence concerns the gene APOE and stroke disorder.