Post-administration of KOK inhibited the increased body weight (by 4.8%), increased serum levels of estradiol (by 61.6%), increased number (by 84.6%) and size of follicular cysts, increased mRNA levels of IL-1β (by 51.8%), IL-6 (by 55.8%), TNF-α (by 74.8%), MCP-1 (by 62.5%), and iNOS (by 76.6%), increased population of rats with estrus cycle arrest compared with DHEA group. Here, IL6 is linked to Follicular Cyst.