A study has shown that NXF3 mediates the downregulation of the levels of TGF-β3 mRNA expression and protein secretion in Sertoli cells (8), but additional studies are required to confirm whether TGF-β3, which is considered to be involved in tumor progression, may be a candidate target gene mediated by NXF3-dependent nuclear export. This evidence concerns the gene TGFB3 and neoplasm.