MAPK8 and chondrosarcoma: Resveratrol has also been found to exhibit diverse biological effects; it induces MMP-9 expression and cell migration via the p38 kinase and PI3K pathway in HT1080 human fibrosarcoma cells (32) and induces differentiation via reduction of the expression of MMPs; this regulation is mediated by the p38 and JNK pathway in HTB94 human chondrosarcoma cells.