CCN2 and neoplasm: Through the combined action of several constituent miRNAs, miR-17∼92 expression has been shown to facilitate tumor angiogenesis by repression of antiangiogenic proteins Tsp1 and CTGF by miR-18a and miR-19a, (13) miR-17 and miR-20 targeting of the TGFβ tumor suppressor pathway (45,46) and miR-17 and miR-20 targeting the E2F transcription factor family (47,48).