AKT1 and Familial prostate cancer: Our previous studies have demonstrated that changes in Akt activity results in the modulation of prostate cancer cell survival, proliferation, colony formation and tumor growth [3-5] as well as micrometastasis of prostate cancer cells via inside-out activation of the cell surface integrin αvβ3, thus aiding the cellular recognition of specific extracellular matrix (ECM) proteins abundant in the vascular basement membrane and bone [6, 7].