AKT1 and Familial prostate cancer: Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase is one of the least characterized substrate of Akt in prostate cancer cells, whose activity is inhibited by Akt via phosphorylation at serine 9 and 21 in GSK-3α and GSK-3β isoforms, respectively [8, 9].