Fig. 1E) [28]. PCAT18 silencing (24-48h) significantly inhibited PCa cell invasion and migration (Fig. 4A, B). At later time points (5 days), PCAT18 silencing induced a significant growth inhibition in both LNCaP and C4-2 cells (Fig. 4C, D), with no effect on non-neoplastic BPH1 cells (Fig. 4E). Prolonged PCAT18 silencing (5 days) also triggered caspase 3/7 activation (Fig. 4F). This evidence concerns the gene CASP3 and posterior cortical atrophy.