CD40 and mantle cell lymphoma: Regarding the immune response profile, as the GSEA analysis identified the cytokine receptor CD40 among the main components of this profile, and as it has been reported that CD40 participates in the survival, cell growth, and drug resistance in MCL [23], we performed a co-stimulation assay of JEKO-1 cells with recombinant CD40L + interleukin-4 (IL4), followed by cell exposure to the different drugs and determination of cell viability.