The sequencing of the BRM promoter in BRM-deficient lung cancer cell lines and primary lung tumors identified two novel germline insertion variants, BRM-741 (rs34480940; 7 bp indel [insertion–deletion] polymorphism) and BRM-1321 (rs3832613 or rs59259177; 6 bp indel polymorphism), that are postulated to recruit MEF2 and histone deacetylases 15. This evidence concerns the gene SMARCA2 and lung carcinoma.