(14) sequenced the coding region of the Noggingene in patients affected with FOP and identifieda 42bp heterozygous deletion in its single exonregion and attributed FOP occurrence to this mutation.In order to investigate the 42bp deletion ofthe reported noggin sequence, Xu et al. (15) examined31 families with 1 or more FOP patients in2000. Here, NOG is linked to fibrodysplasia ossificans progressiva.