Whereas glucose profiles appeared to be mainly influenced by scheduled feeding, insulin profiles reflected body weight gain and body fat mass, with elevated insulin concentrations in ad libitum HF fed rats and 2 × 1 h-HF schedule fed rats becoming apparent after 2 weeks and statistically significant after 5 weeks (Fig. 5E, F), as body weights diverge. The gene discussed is INS; the disease is hydrops fetalis.