We found that the heterozygous microdeletion of exon 5 in ZNF277 does not affect the expression of autism candidate genes IMMP2L and DOCK4. Similarly, a microdeletion involving the 3′ end of DOCK4 (exons 27–52), a gene which lies head-to-head with the ZNF277 gene, and the first three exons of IMMP2L, decreases the expression level of DOCK4 but not ZNF277. Taken together, these data suggest that ZNF277 microdeletions may have a role in SLI susceptibility that is distinct from the autism risk loci described in the AUTS1 region. Here, DOCK4 is linked to autism.