The aim of this study was to evaluate the action of glucans from the Caripia montagnei model on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats and their effects on interleukin levels (IL-1 IL-6), catalase, myeloperoxidase (MPO) enzymes and nitric oxide. Here, IL6 is linked to colitis.