KMT2A and leukemia: The validity of the generated differential gene expression profile as well as the suitability of our experimental approach was supported by the significant enrichment of several gene sets generated by previous studies: Leukemia was the top ranked associated disease term, and direct MLL-AF9 murine targets [13] as well as MLL-AF9 downstream genes detected in transduced neonatal and myeloid as well as lymphoid human primary cells [14] were significantly enriched.