In previous studies we have shown that genes such as AMACR, EZH2, PSGR, PSMA and TRPM8 are tumor-specifically up-regulated in PCa compared to benign tissue and thus, could be used for diagnostic purposes [3-6], whereupon the observed PCa-specific up-regulation of the relevant genes was comparable to those in the present study. Here, AMACR is linked to posterior cortical atrophy.