According to the present and previous studies, Cyr61 produced by RA FLS can initiate a novel cross-talk among FLS, neutrophils and Th17 cells, whereby Cyr61 acts to stimulate IL-8 production by FLS, and the increased IL-8 then acts to promote the migration of neutrophils (Figure 8). Here, CXCL8 is linked to rheumatoid arthritis.