In the second model (after adjustment for all confounders including the variable ADL), the following independent factors predicted the decline of the ability to walk: older age (RR = 1.05 (1.02 to 1.08)), length of time from diagnosis of dementia (RR = 1.16 (1.01 to 1.33)), painful osteoarthritis (RR = 1.84 (1.19 to 2.85)), hospitalization for lower limb fracture (RR = 6.35 (3.02 to 13.37)), higher ADL score (walking item excluded) (RR = 0.49 (0.43 to 0.56)) and use of AChE inhibitors remained in this final model (RR = 0.52 (0.28 to 0.96)). This evidence concerns the gene ACHE and lower extremity fracture.