The Mann and Whitney test reveals that only 4 peptides out of the 56 tested are recognized to different extents by Ab from at least two categories of serums (Figure 5): serums from cirrhotic patients display a significant difference in Ab amount against C15 and NS3-6 compared to chronic patients and against NS4-1 compared to HCC patients. This evidence concerns the gene SOS1 and hepatocellular carcinoma.