PROS1 and colorectal carcinoma: Similar to human CRC, which recapitulates the cell hierarchy of the normal intestinal mucosa [35], [36], we detected in Apc-Ras clones cells with phenotypes reminiscent to ISCs, marked by Delta (Dl) (Figure 4A,C), EEs, marked by Prospero (Pros) (Figure 4A,D, arrow), ECs, marked by the POU domain protein 1 (Pdm1) (Figure 4A,D, arrowhead) and EBs, marked by the expression of Su(H)mCherry (Figure 4E).