Stimulation of 1-LN prostate cancer cells with α2M* causes a 2-3-fold increase in mTOR, Raptor, p-S6K, P-4EBP1, p-AktThr308, and p-AktSer473 in a time and dose-dependent manner [12]. This evidence concerns the gene EIF4EBP1 and Familial prostate cancer.