Moreover intranasal administration of recombinant FIZZ1 during granuloma formation significantly enhances collagen deposition in both WT and TLR-9 KO mice, even though there is no clear differences in granuloma size and Th1/Th2 cytokine profile in the granulomatous lungs [48], indicationg the lack of a suppressor effect on either Th1 or Th2 responses. Here, TLR9 is linked to Granuloma.