FIZZ1 is reported to play significant roles in pulmonary inflammation, airway and vascular remodeling in animal models of allergic inflammation and pulmonary hypertension via upregulating proinflammatory mediators, such as MCP-1, and recruiting inflammatory cells such as macrophages/monocytes in the lung [9], [10], [13]. This evidence concerns the gene CCL2 and pulmonary arterial hypertension.