CD4 and Granuloma: In a mouse lung granuloma model induced by Schistosoma mansoni (Sm) eggs, FIZZ1 KO mice exhibit elevated expression of pathogen-specific CD4+ T cell-derived Th2 cytokines, including IL-4, IL-5 and IL-13, which is accompanied by increased size of egg-induced granuloma and fibrosis compared with their WT counterparts [46].