LIN28A and cancer: Among others, mammalian homologs of Lin-28 significantly contribute to cancer progression, the pluripotency of embryonic stem (ES) cells, early zygote development and the reprogramming of human and mouse fibroblasts to induced pluripotent stem (iPS) cells [23]–[26], mostly by preventing the anti-proliferative function of let-7; thus, the role of Lin-28 in vertebrate development has attracted considerable interest.