NF1 and malignant peripheral nerve sheath tumor: Therefore, the prevention of carcinogenesis of MPNST in the patients with NF1, like a colorectal cancer in the patients with familial adenomatous polyposis [45], the prevention of tumor recurrence after the surgical treatment for MPNST, as well as the therapeutic effect by induction of apoptosis in the treatment of MPNST should be evaluated in future clinical investigation.