One mechanism reported to be responsible for inhibitory effects of MGAT3 on cancer metastasis is that addition of bisecting GlcNAc by MGAT3 hinders β1,6 GlcNAc branching formation catalyzed by MGAT5, since MGAT5 cannot utilize the bisected oligosaccharide as an acceptor substrate [71], [72]. The gene discussed is MGAT5; the disease is cancer.