In the current study, AIS patients were shown to have 10% higher sOB-R level (p = 0.006; FDR-adjusted p = 0.060) and slightly lower serum total leptin level (p = 0.493), thus indicating a higher level of bound leptin and lower level of free leptin that could result in alteration of leptin bioavailability to the target tissues. This evidence concerns the gene LEP and androgen insensitivity syndrome.