SFRP4 and colorectal carcinoma: In addition, among our top deregulated probes, SPON2, RGS16, SFRP4 and CTHRC1 have already been found among the most up-regulated probes in CRC as compared to CRA, and FAM55D, ATOH8, RETNLB, ID4, UGT1A6, and VSIG2, among the most down-regulated probes [11].