Consistently, the frequencies of c.190T>C families on the total number of those that underwent BRCA gene testing and of those carrying pathogenic BRCA1 and BRCA2 mutations were approximately 10-fold higher in cases recruited in Bergamo, around 85% of whom referred to be born in the local area, compared to those observed in families recruited in two large cancer centers in Milan, which attract patients from all over Italy. The gene discussed is BRCA2; the disease is cancer.