BRCA1 and ovarian carcinoma: Conversely, among c.190T>C carriers the median age of ovarian cancer onset (48.2 years) was lower than that observed in 192 BRCA1-positive ovarian cancer patients from the same institutions (51.9 years), suggesting a possible higher risk of ovarian cancer in carriers of the c.190T>C compared to carriers of other BRCA1 mutations.