Kim et al. found a decrease in IL-10 mRNA levels in excisional biopsy specimens from four BCCs after IFN-α treatment compared to pretreatment levels as well as a decrease in IL-10 mRNA levels in 2 BCC-derived cell lines and 2 SCC-derived cell lines following 24-hr IFN-α treatment. This evidence concerns the gene IFNA1 and skin basal cell carcinoma.