IFNA1 and melanoma: Tsavaris et al. treated 14 melanoma patients with local recurrence or distant metastases with IFN-α-2b subcutaneously 3 times per week; the dose was increased from 5 × 106 IU/day for the first week to 10 × 106 IU/day for the second week and to 15 × 106 IU/day thereafter.