IFNA2 and melanoma: High-dose IFN-α2b (HDI) is the approved dosing regimen in the United States for American Joint Committee on Cancer (AJCC) stage IIB-III melanoma and consists of an induction phase of 20 MIU/m2 intravenously (IV) 5 times/week for 4 weeks followed by a maintenance phase of 10 MIU/m2 subcutaneously (SC) 3 times/week for 48 weeks [7].