AGFG1 and neurodegenerative disease: There has been speculation that Rab24 dysfunction might play a role in neurodegenerative disease because mutations placed in a region known as the G2 domain that reduce the affinity of Rab proteins for GTP produce nuclear inclusions that disrupt the nuclear membrane, and stain positive for ubiquitin and Hsp70, typical of protein aggregates in polyglutamine diseases [53].