The investigators anticipate that, like in animal models, IL-12 produced locally by CD8+ T cells will trigger acute inflammation and will induce expression of Fas within tumor-infiltrating macrophages, dendritic cells, and myeloid-derived suppressor cells (MDSC) leading to reversion of dysfunctional antigen presentation in the microenvironment and to eradication of the tumor [33]. The gene discussed is CD8A; the disease is neoplasm.