Additional to its role in protecting cancer cells by suppressing host anti-cancer response, such as apoptosis and senescence, other major pro-cancerous activities of HspB1 are linked to its tumorogenic property which promotes tumor growth and progression [9,14], invasion of tumor cells into surrounding tissues and dissemination to form metastatic colonies [17,18,19,28,29,162,163]. Here, HSPB1 is linked to cancer.