Of interest, HspB1 and Twist expression are both elevated in high-grade prostate cancer tumors and HspB1 enhances the binding of the transcription factor STAT3 to the promoter of the Twist gene [6], an event that subsequently upregulates N-cadherin and downregulates E-cadherin expression, two hallmarks of EMT. This evidence concerns the gene TWIST1 and Familial prostate cancer.