Genome-wide association study data point to a role for the Th17/IL-17 axis in RA, as risk alleles impact Th17 generation and maintenance (IL6R, IL2, IL21, TYK2), trafficking (CCR6) or IL-17A signal transduction (TNFAIP3)[24,25]. Here, TNFAIP3 is linked to rheumatoid arthritis.