In fact, Nievergall and coworkers have shown that CD123 is overexpressed in CD34+CD38- CML cells, compared to normal CD34+CD38- cells: these levels of CD123 expression were higher both in chroinic phase and blast crisis CML patients, with levels increasing upon disease progression [65]. This evidence concerns the gene IL3RA and chronic myelogenous leukemia, BCR-ABL1 positive.