Given these initial observations, Testa and coworkers have explored a large number of AMLs and ALLs with the particular aim of defining a possible overexpression of this membrane receptor compared to the normal counterpart (i.e., normal CD34+ cells), showing that IL-3Rα was overexpressed in 45% of AML patients [35]. The gene discussed is IL3RA; the disease is acute myeloid leukemia.