In fact, a proportion of CD34+/CD38-/CD123+ cells greater than 15% in AML patients with unfavourable karyotype was associated with a lack of complete remission; furthermore, the presence of more than 1% of CD34+/CD38-/CD123+ cells had a negative impact on disease-free survival and overall survival [47]. The gene discussed is CD38; the disease is acute myeloid leukemia.