The correlation between CD123 expression and molecular B-ALL subtypes showed several interesting findings: the CD123 expression in B-ALLs correlated with hyperploid genotype, a frequent genetic abnormality in childhood ALLs; in contrast, B-ALLs associated with other genetic abnormalities, such as ETV6/RUNX1, BCR/ABL1, PBX1/TGF3 translocations or a normal karyotype, did not display CD123 overexpression, compared to normal B-cell precursors [36]. Here, IL3RA is linked to acute lymphoblastic leukemia.