Candidate proteins (N = 21) collectively identified in the ASD versus CTRL set mapped to etiopathologically relevant pathways previously described in neurodevelopmental disorders: energy metabolism (ALDOC, ATP5A1, ATP5B, ATP5H, ECHS1, GAPDH, PGK1, GLUD1), mRNA and protein metabolism (EEF1D, ERP29, HSPA5, HNRNPA2B1, HNRPDL, HNRNPK, HSPD1, PCBP1, PSMA1, PSME2), cytoskeleton (ACTB, TAGLN2) and redox scavenger (PRDX2). This evidence concerns the gene ECHS1 and neurodevelopmental disorder.