Prof. Jianping Ye, Louisiana State University, addressed the Hypoxia in Obesity-From Bench to Bedside. The ATH provides a unified answer to all of the pathological changes in the adipose tissue under obesity, such as chronic inflammation, endoplasmic reticulum stress, leptin expression, adiponectin reduction, adipocyte death and elevated lipolysis. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.