Since TCF7L2, a protein mediating DNA looping for long-distance interactions of distal enhancers and proximal promoters, physically interacts with FOXA1 and AR and mediates the transcription of MYC in breast cancer [19], future investigation will be needed to clarify which co-regulators are involved in FOXA1/AR binding to the enhancer regions upstream of MYC in EC cells. The gene discussed is MYC; the disease is breast cancer.