To determine the respective role of AT2 and AT4 receptors, two groups of 4 weeks diabetes mice were co-treated with AngIV (1.4 mg/kg/d) and respectively the AT4 receptor antagonist Divalinal (2 mg/kg/d) or the specific AT2 receptor antagonist PD123319 (20 mg/kg/d) for 15 days. Here, AGT is linked to diabetes mellitus.