Within the MAPT region, defined from 43.5 Mb to 44.9 Mb on chromosome 17 (Human Genome Build 37) and including PLEKHM1, MAPT, NSF and WNT3 genes, 2,365 SNPs gave evidence for association with PD (P < 10-5 in All-PD). This evidence concerns the gene PLEKHM1 and Parkinson disease.