TGFB1 and diabetic kidney disease: Previously, some studies found that a lot of cell signaling pathway could regulate the diabetic nephropathy fibrosis, such as NF-κB, MAPK, TGF-β and so on [7, 20, 21].The TGF-β signaling pathway has been recognized as an important one in diabetic nephropathy fibrosis, its main biological function being to promote renal cell hypertrophy and regulate ECM metabolism.