Previously, some studies found that a lot of cell signaling pathway could regulate the diabetic nephropathy fibrosis, such as NF-κB, MAPK, TGF-β and so on [7, 20, 21].The TGF-β signaling pathway has been recognized as an important one in diabetic nephropathy fibrosis, its main biological function being to promote renal cell hypertrophy and regulate ECM metabolism. This evidence concerns the gene NFKB1 and diabetic kidney disease.