WNT binding to Frizzled (Fz) results in the activation of Dishevelled (Dsh), which inhibits the activity of GSK3-β, resulting in dephosphorylation and stabilization of beta-catenin, enabling it to accumulate within the nucleus, where it interacts with members of the T-cell factor/lymphocyte enhancer factor (TCF/LEF) family and activate the expression of critical target genes governing cell fate, proliferation, and other processes in several types of cancer [15–20]. Here, CTNNB1 is linked to cancer.