Similar results were obtained by Miners et al. [12] in controls and AD human brains, where no correlation was detected between NEP protein levels and insoluble Aβ in frontal cortex, a circumstance that permits us to speculate if NEP presents greater affinity for oligomeric and soluble forms of Aβ (currently accepted as the main neurotoxic species [29, 30]) than for insoluble Aβ deposits. This evidence concerns the gene MME and Alzheimer disease.