MAPT and Pick disease: Of those with definite bvFTD nine had mutations in the MAPT gene (five harbored the intron 10 + 16 mutation, two harbored the exon 13 R406W mutation, one harbored the exon 10 P301S mutation, and one harbored a novel mutation in exon 12 resulting in a single amino acid substitution at codon 351 (Q351R)), four had mutations in C9ORF72 and one patient who subsequently died was found to have Pick's disease pathology at postmortem.