HMGB1 and hepatocellular carcinoma: To explore the role of the HMGB1-RAGE axis on the cell viability of HCC cells, HCCLM3 cells were treated with anti-HMGB1 neutralizing antibody, anti-RAGE neutralizing antibody, exogenous sRAGE protein, and recombinant human HMGB1(rhHMGB1), respectively.