Experimental data have shown that through the activation of various signaling pathways such as NF-кB, Racl/Cdc42, MAPKs, PI3K/Akt, ERK1/2, SrcK, and HMGB1-RAGE interaction is deeply involved in tumor growth, migration, and metastases [4, 7]. The gene discussed is HMGB1; the disease is neoplasm.