In addition, stroke is the leading cause of permanent disability in adults and poses a significant threat to the quality of life.1, 2 Ischaemic stroke is the predominant stroke type, in most cases attributable to the interception of the middle cerebral artery (MAC).3 To date, recombinant tissue plasminogen activator remains the principal drug approved for pharmacological intervention to salvage the brain. This evidence concerns the gene PLAT and Stroke.