WAS and Wiskott-Aldrich syndrome: Mutations in the gene coding for WASP result in abnormal adhesion and cytoskeletal organisation of leukocytes (including lack of podosomes in myeloid cells) that largely contribute to the phenotype of clinical diseases including the Wiskott Aldrich Syndrome (WAS) and X-linked thrombocytopenia (Calle et al., 2008).