We generated a series of Myc-tagged prostate-cancer-associated mutants of SPOP, including Y87C, Y87N, F102C, S119N, F125V, W131G, F133L, and F133V (Barbieri et al., 2012; Kan et al., 2010), and examined their interaction with AR. The gene discussed is AR; the disease is Familial prostate cancer.