In keeping with this scenario, we have found that Cblb−/− mice are highly susceptible to experimental autoimmune myocarditis (EAM), but it seems that the heightened Th17 responses in EAM observed in Cblb−/− mice are not due to T cell-intrinsic loss of Cbl-b (our unpublished data). Here, CBLB is linked to autoimmune myocarditis.