Plasmid loaded SH-Gel-PEG-peptide and SH-Gel-PEG nanoparticles produced tumor growth inhibition of 50.1% (p < 0.01) and 38.3% (p < 0.05) respectively compared to control group, confirming that wt-p53 gene administration show tumor growth suppression (Figure 1a). This evidence concerns the gene TP53 and neoplasm.