Subcutaneous human pancreatic adenocarcinoma (Panc-1) bearing female SCID beige mice (n = 12) were intravenously dosed with wt-p53 naked and gelatin encapsulated plasmid (20 μg/dose) at day 0, 2 and 4 and tumor volume was monitored as a function of time till the end of the study (day 33). This evidence concerns the gene TP53 and pancreatic adenocarcinoma.